Grenoble Institut des Neurosciences – Centre de Recherche Inserm n°U 836-UJF-CEA-CHU
Directeur : Claude Feuerstein
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Le Secrétariat – Caroline Weber
Tél. : 04 56 52 06 56
Fax : 04 56 52 06 57
Email caroline.weber@ujf-grenoble.fr
Adresse Géographique :
Grenoble Institut des Neurosciences
Centre de Recherche Inserm U.836 – UJF-CEA-CHU
Bâtiment Edmond J. Safra
Chemin Fortuné Ferrini
38700 La Tronche - France
Adresse Postale :
Grenoble Institut des Neurosciences
Centre de Recherche Inserm U.836 – UJF-CEA-CHU
Bâtiment Edmond J. Safra
Université Joseph Fourier
Site Santé à La Tronche
BP 170
38042
POST-DOC POSITION FOR 2 YEARS
The candidate should be well trained in calcium imaging on brain slice or in vivo.
Proposition
A two years post-doctoral position will be available in Grenoble–institute of neurosciences
(France) as for january 2011 to work on a project coordinated by Antoine Depaulis
(antoine.depaulis@ujf-grenoble.fr) untitled : "Do cortical astrocytes play a role in the
occurrence of absence epilepsy ? A calcium imaging and two photon microscopy approach
in a genetic rat model".
The objective of the project is to determine whether absence epilepsy is associated with
the development of an anomaly of the cortical glial network and/or a dysfunction of
neuron-glial relationships during cortical maturation.
The program is developed in collaboration with 4 teams including neurobiologists
specialized in epilepsy and calcium imaging (I Guillemain and M Albrieux) and physicists
specialized in two-photon imaging (JC Vial and B Van der Sanden).
The candidate will focus on experiments that will determine the functional aspects of the
glial network and its relationship with the neural network by measuring spontaneous and
induced calcium movements and cell synchrony on cortical slices of epileptic rat pups and
controls of the same age. The implication of neuro- and glio-transmission in the observed
events will be studied using specific pharmacological tools.
Key words : epileptogenesis, glial network, calcium imaging, neuron-glia relationship,
brain slices, in vivo recording.
Techniques
Calcium imaging in brain slice or in vivo. Confocal or two-photon microscopy
Conditions
Start date : january 2011
Duration : 2 years
Funding : ANR grant (around 26000 euros /year)
Contact
Applications, including a CV, list of publications and names for two references should be
sent by e-mail to: Isabelle Guillemain : isabelle.guillemain@ujf-grenoble.fr and Mireille
Albrieux : mireille.albrieux@ujf-grenoble.fr
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